04 September 2025

USP 4 in Research: Unlocking Dissolution Insights

From innovative release studies to the development of advanced formulations, the USP 4 flow-through cell method continues to offer researchers unique opportunities. Discover how the CE 7smart dissolution tester is being used in cutting-edge research.

The flow-through cell dissolution method remains an indispensable tool in pharmaceutical research—especially for complex or novel dosage forms. Our updated white paper compiles around 100 studies utilizing the CE 7smart system, now filterable by dosage form at sotax.com/science.

A standout example is the recent study, "Feasibility of Hot Melt Extrusion in Converting Water-Based Nanosuspensions into Solid Dosage Forms" (Ragucci et al., 2025), which uses the USP 4 as In-Vitro method.

Why USP 4 with CE 7smart excels in research applications:
 

• Continuous flow and sampling enable high-resolution drug release profiles in both open and closed configurations, across varied flow rates and pH levels.

• Broad compatibility with formats such as microgranules, microspheres, nanosuspensions, hydrogels, and 3D-printed matrices allows robust and reproducible testing of virtually all dosage forms.

• Scientific relevance: The CE 7smart is cited in nearly 100 publications, all accessible via the white paper or our website.

With the CE 7smart Dissolution Tester and USP 4, researchers are equipped for evidence-based, research-driven dissolution testing. Whether you're evaluating new formulations, comparing release kinetics, or refining method validation, our curated collection offers a strong foundation and inspiring case studies.

Stay at the forefront of research. We're here to support your journey.