16 October 2025

Complementary Tools for Smarter Formulation Design

Discover how intrinsic and apparent dissolution together provide deeper insight into drug behavior — helping optimize formulation design, predict bioavailability, and reduce development risks.

Understanding both intrinsic and apparent dissolution is key to predicting drug performance and guiding rational formulation design. Intrinsic dissolution offers mechanistic insight into an API’s inherent solubility and physicochemical behavior under standardized conditions. In contrast, apparent dissolution captures how formulation factors — excipients, particle size, and dosage form geometry — influence real-world dissolution performance.

Advanced dissolution systems such as the USP 4 flow-through cell apparatus further enhance these studies by providing superior hydrodynamic control, high sensitivity to formulation variables, and flexible media handling — enabling more insightful characterization of both APIs and final dosage forms.

Read the full application note, "Intrinsic vs. Apparent Dissolution: Two Approaches to Characterize Dissolution Rate," now available for download.