Content

APW™ Automated
Sample Preparation Workstation

Assay and content/blend uniformity for up to 300 samples
10 mL initial extraction volume using a focused Sonication Probe
Waters Empower™ interface
Powerful dEsign™ variables for streamlined DoE studies

Extraction

After weighing the sample, the APW uses a focused sonication probe coupled with a UV temperature sensor to deliver sample disintegration without over-heating.  Combined with the vortex station, the APW can achieve efficient and reproducible extractions for even the most challenging of sample formulations. Common dosage forms include API, tablets, gels, creams and other lose dose formulations. Cleaning between samples is easily programmed into the method to eliminate sample carry-over. The updated APW is enhanced to reduce cycle times by adding efficiency to the dilution process.

Filtration & Dilution

Consistent volumetric preparations are confirmed gravimetrically at every step throughout the process. The APW filters extracted samples as they are transferred from one processing tube to another. Post filtration, the system can perform up to 1:100,000 dilutions within a single method. For every sample, the system audit trail combined with the advanced error handling capabilities provides a detailed and comprehensive record of the entire preparation process.

Analysis & Storage

The built-in HPLC injector supports on-line analysis. Optionally, all pertinent sample information is transferred to Empower™ as the sample sequence is built by the interface as the APW run-list progresses. In addition to on-line HPLC analysis, samples can also be collected in sealed HPLC vials on the autosampler. Finally, the APW has the capability to transfer samples to a UV spectrophotometer to act as an autosampler for on-line UV analysis.