AT Semi-Automated Off-line (single system)

The new state-of-the-art standard: Xtend™ Dissolution Line – modular, scalable, future-proof

User-friendly and space-saving system to collect samples in LC vials or glass tubes

Flexibly driven by EasyTouch™ interface or WinSOTAXplus Dissolution Software

Collection of samples by Syringe Pump Module or CP Piston Pump through HollowShaft™ or AutoLift™

Options for media replacement, filter and media change, and capacity extension

100% visibility and CenterView™ video monitoring

The innovative circular design of the dissolution bath opens up a new dimension of observation possibilities for R&D visualization and OOS troubleshooting. Understanding the release characteristics of formulations requires full visibility of samples during the dissolution test. Depending on your observation needs, the circular AT bath allows visual observation of each vessel from the outside and additionally from the inside using video monitoring. To view the behavior of samples from the bottom, an optional mirrored base plate is available.
The unique CenterView™ design provides perfect visualization and video recording of release processes in each vessel. Located in the center of the dissolution bath, all cameras can be adjusted and controlled for height and focal distance. For optimum visibility, indirect light is integrated into this space-saving design.

Precise temperature control and easy handling & cleaning

The innovative circular design of the dissolution bath sets new standards for precise, quick and easy operation. Like its predecessor models, the AT dissolution bath has been optimized for ideal water circulation to ensure extremely high temperature homogeneity during the test. From fast filling and draining of the water bath with quick-connector, self-priming circulation pump, to motorized lift function, all handling and cleaning processes of the AT have been optimized for simple and fast execution. When adding test medium or removing vessels, the vertically lifted shaft drive provides excellent accessibility during all change-over and cleaning processes.

Flexibility maximized - suited for all dosage forms

Large inlet dimensions provide for a wide variety of tablet and sinker types to be introduced manually or automatically.

From standard tablets to capsules with large sinkers – the dissolution bath is capable of handling virtually all dosage forms.

Samples are protected from media before test start. As the inlets are closed during the test, media evaporation is prevented.

Flexibility maximized - various vessel styles

For full flexibility, the dissolution apparatus can be operated with various vessel types. The bath accommodates a broad variety of different vessel styles – from certified standard glass vessels to polycarbonate or low actinic glass vessels, 1 or 2 liter vessels, mini vessels, immersion cell vessel, peak vessels, and China vessels.

Flexibility maximized - USP 1,2,5,6 methods and more

Developed for USP 1,2,5,6 methods, the dissolution apparatus allows testing with different compliant and also non-compliant stirrer designs: Basket, Paddle, Paddle over disk, Rotating Cylinder, Extraction Cell, Mini Paddle, China Paddle, Stationary Basket, Intrinsic Dissolution. All parts are made of high quality material, are serialized and certified.

Complete Sampling Solutions

Automating the sampling process improves accuracy, reproducibility and simplifies method transfer. Standardized modules for sample withdrawal allow sampling tailored to your application. For dissolution sample withdrawal, four key factors must be considered: height reproducibility, automation potential, hydrodynamic impact and possible coupling to temperature monitoring. Automating the process with simultaneous sampling and automatic pumping improves time and volume accuracy. Based on your requirements, SOTAX dissolution baths offer a wide variety of manual and automatic sampling possibilities:

  • Simple manual sample withdrawal using a glass pipette
  • Stand-alone type sampling probe with additional pipette guide
  • Stationary cannula in different materials and diameters for sampling with disposable syringes
  • Automatic simultaneous sampling with the unique HollowShaft™ – reducing hydrodynamic perturbation
  • Automatic simultaneous sampling with cannula and AutoLift™ (AT Xtend™ only) for maximum flexibility

User-friendly with EasyTouch™

Simple and intuitive touch screen operation makes test set-up and method programming easier than ever. Logical, icon-based menu structures and multi-language capability reduce analyst training times to a minimum. The large integrated 5.4" color touch screen sets new standards for efficient operation. User rights settings, method programming, data visualization, data transfer and reporting are readily available at the touch of a button. Using the built-in USB port, methods can be conveniently exchanged between different AT installations – eliminating redundant programming tasks. Various communication ports allow local and network printing, status monitoring via TCP/IP and full system control by PC software whenever needed.

Off-line analysis

Workload increase or method changes often call for maximum flexibility and modular and scalable sample management devices. They also require safe and reproducible collection and storing as well as logical programming. An off-line configuration offers simplicity and flexibility as the samples once stored in glass tubes or LC vials can be conveyed to any kind of analytical device in all kind laboratory set-ups.